Is a complex, well-orchestrated and an overlapping series of events from the time of initial tissue injury towards wound closure. In the case of acute wounds, the process is highly coordinated phases of hemostasis, inflammation, proliferation, and remodeling. However the wound healing cascade may be arrested in any of these phases, leading to the formation of a chronic non-healing wound. And that maybe due to intrinsic and extrinsic factors that failed to support the process leading to chronicity or the hard healing state.
Phase 1 – Hemostasis:
Acute wounds cause vascular injury and bleeding from the wound, and the immediate priority is to prevent blood loss by vasoconstriction and formation of a blood clot to seal the vessel. The coagulation and complement cascades are then initiated to form fibrin which are the clot.
Phase 2 – Inflammation:
The phase where the aide of neutrophils, macrophages, and lymphocytes are into action to combat the infectious process to occur.
Phase 3 – Proliferation:
Granulation tissue has formed. It is a dense conglomeration of blood vessels, macrophages and fibroblasts embedded within a loose matrix of fibronectin, hyaluronic acid, and collagen. All of these factors necessary to advance into the next phase.
Phase 4 – Remodeling phase:
Remodeling of wound tissue occurs over a prolonged time and may last up to 1 year. It is characterized by wound contraction and collagen remodeling.
Current concepts in the physiology of adult wound healing. (2015). Retrieved from https://parjournal.net/article/view/1211